PRODUCT DETAILS

Composition:

Artemether 80 mg

Lumefantrine 480 mg 

Uses/Indication:

Treatment of acute uncomplicated malaria caused by Plasmodium falciparum and mixed species.

Direction of Use:

Adults & children ≥35 kg: Day 1: 1 tablet initially and 1 tablet again after 8 hours

Days 2 & 3: 1 tablet BID (12 Hourly interval)

Side Effects:

Common: headache, dizziness, nausea

Less common: QT prolongation, electrolyte imbalance (especially hypokalaemia or hypomagnesemia)

Warnings/Interactions:

Contraindications: Known QT prolongation, serious cardiac arrhythmias.

Interactions:

Avoid grapefruit juice and CYP3A4 modulators (e.g., azoles, rifampin)

May interact with other QT-prolonging drugs (e.g., certain antimalarials, antipsychotics)

Caution: 

Monitor in patients with electrolyte disturbances, liver or kidney impairment, or on cardioactive medications

Not recommended in the first trimester of pregnancy unless there is no other alternative treatment available

Therapeutic note: Fat-containing food improves lumefantrine absorption significantly