Evening Primrose Oil (EPO): common dosage is 500 mg to 1300 mg per capsule, standardized to provide approximately 50–130 mg Gamma-Linolenic Acid (GLA) per capsule
Vitamin E: often added (~10 mg) as antioxidant
Capsule shell (gelatin, glycerol, carrageenan or modified starch)
Traditionally used to manage premenstrual syndrome (PMS) symptoms like breast tenderness, irritability, bloating, and acne
May support skin health, including conditions like eczema or acne
Occasionally used in attempts to support hormonal balance, joint discomfort or diabetic neuropathy, though evidence remains limited
Typically taken once daily, with food, to improve absorption and reduce gastrointestinal upset
Capsules should be swallowed whole, not chewed
Common (mild): upset stomach, nausea, soft stools or diarrhea, headache
Rare/serious: allergic reactions (rash, itching/swelling, difficulty breathing). Those with seizure disorders may experience increased seizure risk
May increase bleeding risk, especially when taken with anticoagulants (e.g. warfarin), antiplatelet agents, NSAIDs, aspirin, garlic, ginger, etc.
Use caution if you have epilepsy or seizure disorders, as EPO may provoke seizures
May affect levels of certain drugs, including lithium, phenothiazines, and lopinavir/ritonavir
Those with hormone-sensitive conditions (e.g. estrogen‑sensitive cancers) or during late pregnancy should avoid use; may delay labor or impact hormone levels
Stop at least 2 weeks before surgery to reduce bleeding risk
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