1. Composition

• Bendrofluazide – 2.5 mg per tablet
• Excipients: starch, lactose, microcrystalline cellulose, magnesium stearate, and other tablet excipients

Drug class:

• Thiazide diuretic

2. Uses / Indications

Bendrofluazide is used for:

• Hypertension – to lower blood pressure
• Edema associated with:
• Heart failure
• Liver cirrhosis
• Renal disease (nephrotic syndrome)
• Occasionally used for prevention of kidney stones (reducing calcium excretion)

Mechanism:

• Inhibits sodium and chloride reabsorption in the distal convoluted tubule, leading to mild diuresis and reduction in blood pressure.

3. Direction for Use

• Adults: Usually 2.5–5 mg once daily, taken in the morning
• Children: Dose determined by a physician based on weight
• Take with or without food
• Avoid taking late in the day to prevent nocturia

4. Side Effects

Common:

• Frequent urination
• Electrolyte disturbances (low potassium, sodium, magnesium)
• Dizziness or hypotension
• Muscle cramps or weakness

Rare:

• Hyperglycemia
• Allergic reactions
• Photosensitivity
• Gout flare (due to uric acid retention)

5. Warnings / Interactions / Cautions

• Monitor electrolytes, kidney function, and blood pressure regularly
• Use cautiously in patients with:
• Kidney disease
• Diabetes
• Gout
• Heart disease
• May interact with:
• ACE inhibitors, digoxin, lithium, corticosteroids, NSAIDs
• Pregnancy and breastfeeding: only if clearly indicated and monitored
• Take adequate water to avoid dehydration
• Avoid sudden discontinuation without medical advice