PRODUCT DETAILS

Composition:
Isosorbide dinitrate 10mg

Uses / Indication:

Prevention and treatment of angina pectoris (chest pain caused by coronary artery disease)

Heart failure (often combined with other medicines like hydralazine)

Pulmonary hypertension (in some cases)

Post–myocardial infarction management (after heart attack in selected patients)

Direction of Use:

Usually taken 2–3 times daily or as prescribed by a healthcare provider

Often with a nitrate-free interval (10–14 hours) each day to prevent tolerance

Side Effects:

Common;

Headache (very common with nitrates)

Dizziness or light-headedness

Flushing

Low blood pressure

Fast heartbeat (tachycardia)

Nausea

Less Common / Serious

Severe hypotension

Syncope (fainting)

Reflex tachycardia

Methemoglobinemia (rare with high doses)

 Warnings/Interactions:

Use cautiously in patients with:

Severe hypotension

Hypovolemia (low blood volume)

Recent head injury or increased intracranial pressure

Severe anaemia

Hypertrophic cardiomyopathy

Right ventricular infarction

Other warnings:

Tolerance may develop with continuous use.

Must maintain a nitrate-free interval daily.

May cause postural hypotension (dizziness when standing).

Interactions: 

Major (Avoid completely)

Sildenafil

Tadalafil

Vardenafil

Combination can cause life-threatening hypotension.

Other interactions

Antihypertensives → additive blood pressure lowering

Alcohol → increased dizziness/hypotension